BiohacksAI/Mechanism Hypothesis/Wortmannin

Wortmannin — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

TDP1THRBCHAINRATTUSNUCLEARABCB1EUCHROMATICVDRMAPTSTK33IL1BHSP90AA1MTORPOLIEPAS1PHOSPHATIDYLINOSITOLPLK1PIK3CGHNF4APLIN5PIK3R1PIK3CDPIK3CBPIK3CADNA-DEPENDENTMYLKPIK3R5PIK3C3PLK3PI4KBPI4KAPLK2PRKDC

33 known targets mapped from PubChem bioassay data

Pathway Context

Phospholipid metabolism8 targets overlapping

PI Metabolism8 targets overlapping

Regulation of T cell activation by CD28 family7 targets overlapping

Uncovered Pathway Targets

170 total

ACHEBCHEBMXCSNK2A1CSNK2A2CSNK2BINPPL1MGLLPHOSPHO1PI4K2A+160 more…

Genes present in the top pathway union that Wortmannin does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 44 targets covered · evidence score 44.2

score 12,513.413

ADRM1HIF1ANFE2L2NFKB1NFKB2PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7+32

Sorafenib

#2 gap-filler · 25 targets covered · evidence score 44.4

score 6,564.007

CSKEZH2FYNGSK3BLCKLYNPTPN6SRCYES1CAMK2BFGFR1FGFR2+13

589 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.