Yohimbine — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2D6CYTOCHROMEESRRACYP3A7RATTUSEUCHROMATICDRD35-HYDROXYTRYPTAMINEADRA1AHOMOHTR2ADRD2DRD1AHRHTR1AADRA2AADRB2HTR2BADRA2CADRA2BALPHA-2AADRA1BADRA1DALPHA-2BHTR7HTR6ALPHA-1DALPHA-1AALPHA-2CDRD4ALPHA-1BHTR1BHTR1DHTR5ACACNA1CHTR1FHTR1EDRD5GHSR
39 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)19 targets overlapping
Amine ligand-binding receptors18 targets overlapping
Adrenoceptors7 targets overlapping
Uncovered Pathway Targets
208 totalADORA2BADORA3ADRB1ADRB3AGTR1AGTR2APLNRAPPAVPR1AAVPR1B+198 more…
Genes present in the top pathway union that Yohimbine does not directly modulate.
Top Stack Candidates
Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on
score 9,052.97#1 gap-filler · 29 targets covered · evidence score 44.3
ADRB1ADRB3TSHRCREB1GRK2TAS2R1TAS2R10TAS2R13TAS2R14TAS2R16TAS2R19TAS2R20+17
Astemizole Antihistamine drug now withdrawn from
score 4,018.989#2 gap-filler · 17 targets covered · evidence score 48.7
APLNRAVPR1ACHRM1CHRM2CHRM3GALR2HRH1HRH2HRH4HTR2CMLNROXTR+5
640 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.