2-Acetylaminofluorene — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C19ARCYP2C9NR1I2ESR1CYTOCHROMECYP1A2ESRRACYP3A4NFE2L2PGRNUCLEARNR3C1RARA5-HYDROXYTRYPTAMINEAHRTSHRATAD5SODIUM-DEPENDENTALPHA-2AHDAC9AMINE
22 known targets mapped from PubChem bioassay data
Pathway Context
Nuclear Receptor transcription pathway7 targets overlapping
SUMOylation6 targets overlapping
SUMO E3 ligases SUMOylate target proteins6 targets overlapping
Uncovered Pathway Targets
121 totalESR2ESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1NR1D2+111 more…
Genes present in the top pathway union that 2-Acetylaminofluorene does not directly modulate.
Top Stack Candidates
Progesterone
score 4,325.679#1 gap-filler · 17 targets covered · evidence score 50.6
ESR2ESRRGHNF4AHNF4GNR1H2NR1H4NR2F1NR3C2NR4A2NR5A1NR5A2RARB+5
Luteolin 5,7,3',4'-tetrahydroxy-flavone,
score 3,295.858#2 gap-filler · 16 targets covered · evidence score 40.6
NR1H2NR1H3PPARGAURKBBLMNFKB2PARP1RELATOP1WRNCBR3CYP19A1+4
685 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.