Adapalene — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
ARESR1THRBNFE2L2SYKTYROSINE-PROTEINPGRRORCNUCLEARTP53NR3C1RARACYP19A1NR1H4HSPB1USP1CACNA1CHSPD1HSPE1GLRA1USP8USP10RARBRARGRETINOIC
25 known targets mapped from PubChem bioassay data
Pathway Context
Nuclear Receptor transcription pathway8 targets overlapping
SUMOylation7 targets overlapping
SUMO E3 ligases SUMOylate target proteins7 targets overlapping
Uncovered Pathway Targets
121 totalESR2ESRRAESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1+111 more…
Genes present in the top pathway union that Adapalene does not directly modulate.
Top Stack Candidates
Progesterone
score 3,739.471#1 gap-filler · 15 targets covered · evidence score 50.6
ESR2ESRRAESRRGHNF4AHNF4GNR1H2NR1I2NR2F1NR3C2NR4A2NR5A1NR5A2+3
Quercetin
score 3,728.182#2 gap-filler · 18 targets covered · evidence score 43.4
ESRRANR1I2PPARGRXRAAURKBBLMNFKB2RELATOP1TOP2ACREB1HSP90AA1+6
585 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.