Aprindine — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
KCNH2DRD35-HYDROXYTRYPTAMINEADRA1AADRA2CSLC6A4SLC6A2HTR2CKAPPA-TYPEHRH1
10 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)5 targets overlapping
Amine ligand-binding receptors5 targets overlapping
G alpha (q) signalling events3 targets overlapping
Uncovered Pathway Targets
339 totalADORA2BADORA3ADRA1BADRA1DADRA2AADRA2BADRB1ADRB2ADRB3AGTR1+329 more…
Genes present in the top pathway union that Aprindine does not directly modulate.
Top Stack Candidates
Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on
score 9,878.253#1 gap-filler · 34 targets covered · evidence score 44.3
ADRA1BADRA1DADRB1ADRB2ADRB3DRD2DRD4TSHRCREB1GRK2TAS2R1TAS2R10+22
Aripiprazole
score 8,475.751#2 gap-filler · 38 targets covered · evidence score 52.0
ADORA3ADRA1BADRA1DADRA2AADRA2BADRB1ADRB2ADRB3AGTR1AVPR1ACHRM1CHRM2+26
819 more candidates · full stack optimisation locked
Enter your API token to unlock the complete analysis.
BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.