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Aripiprazole

A piperazine and quinolone derivative that is used primarily as an antipsychotic agent. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, where it also functions as a post-synaptic antagonist, and an antagonist of SEROTONIN RECEPTOR, 5-HT2A. It is used for the treatment of SCHIZOPHRENIA and BIPOLAR DISORDER, and as an adjunct therapy for the treatment of depression.

298+ PubMed studies analyzed · 24 RCTs · Evidence Score: 53.9

Research Domains

Aripiprazole has been studied across 18 research domains including 🌤️ Mood & Depression, 🧠 Focus & Attention, 🧠 Neuroprotection, ❤️ Cardiovascular, 😴 Sleep. The primary research focus is 🌤️ Mood & Depression with 21% of studies addressing this area.

Similar Compounds by Shared Targets

The following compounds share molecular targets with Aripiprazole, based on binding affinity data from BindingDB and ChEMBL. Sorted by shared target overlap.

Mianserin
37 shared targets
Amoxapine
42 shared targets
Metergoline
43 shared targets
brexpiprazole
28 shared targets
Buspirone
32 shared targets
Cyproheptadine
38 shared targets
Lysergic
30 shared targets
Loxapine
28 shared targets
risperidone
27 shared targets
Bromocriptine
33 shared targets
Loading evidence profile...

This evidence profile for Aripiprazole is generated deterministically from 298 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.