Arecoline — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
GLI3RATTUSCHRM1CHRM2CHRM5CHRM4CHRM3MUSCARINICGNRHRTRHRCHRNA4CHRNA7CHRNB2CHRNA10CHRNB4CHRNA3CHRNA9CHRNA5CHRNA2CHRNA6CHRNB3
21 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)7 targets overlapping
G alpha (q) signalling events5 targets overlapping
Amine ligand-binding receptors5 targets overlapping
Uncovered Pathway Targets
220 totalADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2+210 more…
Genes present in the top pathway union that Arecoline does not directly modulate.
Top Stack Candidates
Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on
score 10,137.337#1 gap-filler · 36 targets covered · evidence score 44.3
ADRA1AADRA1BADRA1DADRB1ADRB2ADRB3DRD2DRD3DRD4TSHRCREB1GRK2+24
Aripiprazole
score 6,729.618#2 gap-filler · 32 targets covered · evidence score 52.0
ADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1AVPR1A+20
688 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.