Aripiprazole — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2D6ARCYP2C9NR1I2ESR1TDP1THRBESRRACYP3A7SYKTYROSINE-PROTEINGLI3RATTUSRORCMUSABCB1KCNH2CHRM1DRD35-HYDROXYTRYPTAMINEADRA1AHTR2ADRD2DRD1HTR1AADRA2AADRB2HTR2BADRA2CADRA2BSLC6A3ACHEPMP22SLC6A4MU-TYPESLC6A2HTR2CSODIUM-DEPENDENTCHRM2HRH1MDM2MDM4ANDROGENADRB1ADORA3ADRA1BADRA1DHRH2HTR7HTR6DRD4MAOAHTR1BADRB3RGS4HTR1DGPR32HTR5ATBXA2RMAP4K2CGMP-INHIBITEDPLA2G7TAAR1DRD5HTR3AAPAF1HRH3TACR1AGTR1SLC18A2HTR3BAVPR1AMLNRGNA15MAP3K3HTR3CHTR3DHTR3EH1-0
79 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)32 targets overlapping
Amine ligand-binding receptors26 targets overlapping
G alpha (q) signalling events15 targets overlapping
Uncovered Pathway Targets
280 totalADORA2BAGTR2APLNRAPPAVPR1BAVPR2BDKRB1BDKRB2C5CCKBR+270 more…
Genes present in the top pathway union that Aripiprazole does not directly modulate.
Top Stack Candidates
gamma-Aminobutyric Acid
score 4,929.67#1 gap-filler · 19 targets covered · evidence score 43.1
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRG2+7
Colchicine
score 4,877.485#2 gap-filler · 20 targets covered · evidence score 42.1
CXCL8GLRA1GLRA2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBA8TUBAL3TUBB1+8
644 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.