Atorvastatin — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
ARNR1I2THRBESRRACYP3A4SYKNSD2RORCCYP19A1NTMT1NR1H4CASP3CASP7GPR151SLCO1B1ABCG2SLCO1B3SLCO2B1HMGCRRHOCSREBF2
21 known targets mapped from PubChem bioassay data
Pathway Context
Metabolism of steroids6 targets overlapping
Drug ADME5 targets overlapping
Nuclear Receptor transcription pathway4 targets overlapping
Uncovered Pathway Targets
117 totalABCB11ABCC3AKR1C1AKR1C2AKR1C3AKR1C4ALBCARM1CREBBPCYP11B1+107 more…
Genes present in the top pathway union that Atorvastatin does not directly modulate.
Top Stack Candidates
Progesterone
score 6,134.395#1 gap-filler · 27 targets covered · evidence score 50.6
ABCB11AKR1C4RXRASERPINA6ABCB1CYP2C19CYP2C9CYP2D6SLC22A1SLC22A3ESR1ESR2+15
Gemfibrozil
score 3,575.612#2 gap-filler · 15 targets covered · evidence score 51.5
PPARARXRAABCC2CYP2C19CYP2C8CYP2C9NR1H2NR2F1NR5A1NR5A2RARARARB+3
826 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.