Bosentan — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
NR1I2CYTOCHROMEESRRACYP3A4NFE2L2GLI3RATTUSRORCHOMOABCC2NR1I3EDNRANR1H3EDNRBENDOTHELIN-1ENDOTHELIN
16 known targets mapped from PubChem bioassay data
Pathway Context
Nuclear Receptor transcription pathway4 targets overlapping
Drug ADME2 targets overlapping
Class A/1 (Rhodopsin-like receptors)2 targets overlapping
Uncovered Pathway Targets
264 totalARESR1ESR2ESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1+254 more…
Genes present in the top pathway union that Bosentan does not directly modulate.
Top Stack Candidates
Astemizole Antihistamine drug now withdrawn from
score 8,255.635#1 gap-filler · 45 targets covered · evidence score 48.7
ARESR1ESR2PGRPPARDPPARGRARAABCB1CYP2C19CYP2C9CYP2D6ADRA1A+33
Aripiprazole
score 7,322.002#2 gap-filler · 38 targets covered · evidence score 52.0
ARESR1ABCB1CYP2C9CYP2D6ADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2C+26
1063 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.