BiohacksAI/Mechanism Hypothesis/Cilostazol

Cilostazol — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6CYP2C9NR1I2ESR1CYTOCHROMETDP1ESRRACYP3A4CYP3A7NFE2L2GLI3NSD2HISTONE-LYSINEDRD1TSHRACHEKAPPA-TYPEALDEHYDERXRANR5A1NR5A2CGMP-INHIBITEDNPY1RTHYROIDNPY2RADCY9PDE3APDE3B

29 known targets mapped from PubChem bioassay data

Pathway Context

Biological oxidations6 targets overlapping

Phase I - Functionalization of compounds6 targets overlapping

Cytochrome P450 - arranged by substrate type6 targets overlapping

Uncovered Pathway Targets

122 total

AADACAHCYAHRALDH1A1ALDH2AOC1ARNTCBR3CES1CES2+112 more…

Genes present in the top pathway union that Cilostazol does not directly modulate.

Top Stack Candidates

Progesterone

#1 gap-filler · 18 targets covered · evidence score 50.6

score 4,203.836

CYP1A2NR1H4ARESR2ESRRGHNF4AHNF4GNR1H2NR2F1NR3C1NR3C2NR4A2+6

Quercetin

#2 gap-filler · 20 targets covered · evidence score 43.4

score 3,513.892

AHRCYP19A1CYP1A1CYP1A2CYP1B1CYP2C8HSP90AB1MAOANNMTARNR3C1PGR+8

692 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.