Clobetasol — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
ARTDP1NR3C1AHR
4 known targets mapped from PubChem bioassay data
Pathway Context
SUMOylation2 targets overlapping
SUMO E3 ligases SUMOylate target proteins2 targets overlapping
Nuclear Receptor transcription pathway2 targets overlapping
Uncovered Pathway Targets
129 totalAURKAAURKBBIRC5BLMBRCA1CREBBPCTBP1DNMT1DNMT3BEIF2AK2+119 more…
Genes present in the top pathway union that Clobetasol does not directly modulate.
Top Stack Candidates
Bortezomib
score 12,876.138#1 gap-filler · 47 targets covered · evidence score 44.2
ESR1HDAC1HDAC2MITFNFKB2NR1I2PARP1PGRRARARELATP53ESR2+35
Progesterone
score 5,196.051#2 gap-filler · 23 targets covered · evidence score 50.6
ESR1NR1H2NR1H4NR1I2NR3C2NR4A2NR5A1NR5A2PGRRARARORARXRA+11
674 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.