Corticosterone — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C19ARCYP2C9NR1I2CYP1A2THRBESRRANFE2L2GLI3PGRRORCNUCLEARNR3C1TSHRCREB1SHBGSERPINA6SLC22A1SLC22A2NR3C2EIF4HSLCO1A1SLC22A3SCARB1
24 known targets mapped from PubChem bioassay data
Pathway Context
Nuclear Receptor transcription pathway6 targets overlapping
Drug ADME5 targets overlapping
SUMOylation5 targets overlapping
Uncovered Pathway Targets
115 totalESR1ESR2ESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1+105 more…
Genes present in the top pathway union that Corticosterone does not directly modulate.
Top Stack Candidates
Progesterone
score 4,465.998#1 gap-filler · 19 targets covered · evidence score 50.6
ESR1ESR2ESRRGHNF4AHNF4GNR1H2NR1H4NR2F1NR4A2NR5A1NR5A2RARA+7
Gemfibrozil
score 3,682.897#2 gap-filler · 14 targets covered · evidence score 51.5
NR1H2NR2F1NR5A1NR5A2PPARARARARARBRARGRORARXRAABCC2CYP2C8+2
806 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.