BiohacksAI/Mechanism Hypothesis/Dactinomycin

Dactinomycin — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2D6ARESR1CYTOCHROMETDP1THRBESRRACYP3A7NFE2L2CHAINGLI3PGRRORCNUCLEARTP53NR3C1ABCB1RARAEUCHROMATICHOMOESR2CYP19A1IFNGPPARGVDRATXN2NR1H4SMAD3RXRASMAD2IFNB1CREB1CASP3YAP1TOP1P1PPARDHLA-BHTTCASP7ALOX15GAPDHUSP17L5DDR2GRB2NRP2RAD51VEGFC

47 known targets mapped from PubChem bioassay data

Pathway Context

Nuclear Receptor transcription pathway12 targets overlapping

SUMOylation10 targets overlapping

SUMO E3 ligases SUMOylate target proteins10 targets overlapping

Uncovered Pathway Targets

117 total

ESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1NR1D2NR1H2+107 more…

Genes present in the top pathway union that Dactinomycin does not directly modulate.

Top Stack Candidates

Progesterone

#1 gap-filler · 14 targets covered · evidence score 50.6

score 3,909.933

ESRRGHNF4AHNF4GNR1H2NR1I2NR2F1NR3C2NR4A2NR5A1NR5A2RARBRARG+2

Quercetin

#2 gap-filler · 15 targets covered · evidence score 43.4

score 3,327.647

NR1I2AURKBBLMNFKB2RELATOP1TOP2AHSP90AA1HSP90AB1HSPB1IGF1RKDM1A+3

497 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.