BiohacksAI/Mechanism Hypothesis/Pueraria

Pueraria — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6CYP2C9NR1I2ESR1CYP1A2THRBESRRACYP3A4CYP3A7NFE2L2GLI3TP53NR3C1RARAHTR2AESR2AHRNTMT1ATAD5YAP1HDAC9CA7CA12CA4HTTHDAC6TXNRD1SMN2AKR1B10MRGPRX1RAB9APIM2NPC1UGT1A1TRPC5BAP1ESRRGSULT1A1RACGAP1ALDH2ESRRB

42 known targets mapped from PubChem bioassay data

Pathway Context

Biological oxidations9 targets overlapping

Phase I - Functionalization of compounds8 targets overlapping

Nuclear Receptor transcription pathway8 targets overlapping

Uncovered Pathway Targets

80 total

AADACAHCYALDH1A1AOC1ARNTCBR3CES1CES2CYP11B1CYP11B2+70 more…

Genes present in the top pathway union that Pueraria does not directly modulate.

Top Stack Candidates

Progesterone

#1 gap-filler · 15 targets covered · evidence score 50.6

score 3,855.323

NR1H4RXRAARHNF4AHNF4GNR1H2NR2F1NR3C2NR4A2NR5A1NR5A2PGR+3

Gemfibrozil

#2 gap-filler · 10 targets covered · evidence score 51.5

score 2,835.293

CYP2C8RXRANR1H2NR2F1NR5A1NR5A2PPARARARBRARGRORA

532 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.