BiohacksAI/Mechanism Hypothesis/Daunorubicin

Daunorubicin — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2D6ARNR1I2ESR1CYTOCHROMETDP1CYP1A2THRBESRRACYP3A4CYP3A7NFE2L2SYKTYROSINE-PROTEINCHAINGLI3PGRNSD2RORCHISTONE-LYSINENUCLEARTP53NR3C1ABCB1RARAEUCHROMATICCHRM1HTR2AESR2CYP19A1IFNGPPARGVDRATXN2ATAD5PMP22NR1H4SMAD3MAPTSTK33PTGS2SMAD2IFNB1POLKCREB1CASP3YAP1HDAC9TOP1P1PPARDHLA-BHTTHDAC6CASP7RAPGEF4RAPGEF3USP1GNRHRABCG2ESTROGENBLMABCC1GNAI1RGS12PARP1CGASTOP2AGHSRPOLYHDAC10HDAC11HDAC4HDAC5HDAC7HDAC1HDAC2HDAC3HDAC8AVPR1ATOP1CBFBRUNX1TOR1ACCDC88AGNAI3ND4XAA-PRO

87 known targets mapped from PubChem bioassay data

Pathway Context

SUMOylation18 targets overlapping

SUMO E3 ligases SUMOylate target proteins18 targets overlapping

Signaling by NOTCH15 targets overlapping

Uncovered Pathway Targets

162 total

AURKAAURKBBIRC5BRCA1CREBBPCTBP1DNMT1DNMT3BEIF2AK2EP300+152 more…

Genes present in the top pathway union that Daunorubicin does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 38 targets covered · evidence score 44.2

score 11,647.086

MITFNFKB2RELAADRM1ELANEHIF1APSMA1PSMA2PSMA3PSMA4PSMA5PSMA6+26

Progesterone

#2 gap-filler · 15 targets covered · evidence score 50.6

score 4,311.72

NR1H2NR3C2NR4A2NR5A1NR5A2RORARXRAADAM10ESRRGHNF4AHNF4GNR2F1+3

396 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.