Dehydroepiandrosterone Sulfate — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
THRBPPARGVDRMAPTRXRAUSP1TRPA1CASP1FFAR1KCNK10OXER1
11 known targets mapped from PubChem bioassay data
Pathway Context
SUMOylation3 targets overlapping
SUMO E3 ligases SUMOylate target proteins3 targets overlapping
Nuclear Receptor transcription pathway3 targets overlapping
Uncovered Pathway Targets
220 totalARAURKAAURKBBIRC5BLMBRCA1CREBBPCTBP1DNMT1DNMT3B+210 more…
Genes present in the top pathway union that Dehydroepiandrosterone Sulfate does not directly modulate.
Top Stack Candidates
Astemizole Antihistamine drug now withdrawn from
score 7,782.688#1 gap-filler · 41 targets covered · evidence score 48.7
ARBRCA1ESR1MDM2MITFPGRRARATP53ESR2ESRRAPPARDADRA1A+29
Fluoxetine
score 7,226.439#2 gap-filler · 26 targets covered · evidence score 73.4
ARESR1RARAESR2ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CCCKBRCHRM3+14
944 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.