Dehydroepiandrosterone — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C19ARCYP2C9NR1I2ESR1THRBESRRACYP3A7GLI3PGRRORCNR3C1ESR2NR1H4SHBGGPR32SERPINA6GPBAR1TARDBPG6PD
20 known targets mapped from PubChem bioassay data
Pathway Context
Nuclear Receptor transcription pathway8 targets overlapping
SUMOylation6 targets overlapping
SUMO E3 ligases SUMOylate target proteins6 targets overlapping
Uncovered Pathway Targets
122 totalESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1NR1D2NR1H2+112 more…
Genes present in the top pathway union that Dehydroepiandrosterone does not directly modulate.
Top Stack Candidates
Bortezomib
score 12,335.364#1 gap-filler · 42 targets covered · evidence score 44.2
PPARDRARAHDAC1HDAC2MITFNFKB2PARP1RELATP53ADRM1HDAC3PSMA1+30
Progesterone
score 4,271.441#2 gap-filler · 16 targets covered · evidence score 50.6
ESRRGHNF4AHNF4GNR1H2NR2F1NR3C2NR4A2NR5A1NR5A2RARARARBRARG+4
465 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.