Dihydroergotamine — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C19CYP2D6ARCYP2C9NR1I2CYTOCHROMETHRBESRRACYP3A4DRD35-HYDROXYTRYPTAMINEADRA1AHTR2ADRD2DRD1HTR1AADRA2AADRB2HTR2BTSHRADRA2CADRA2BACHEPMP22HTR2CALPHA-2AADRA1BADRA1DALPHA-2BHRH2HTR7HTR6ALPHA-1DALPHA-1AALPHA-2CALPHA-1BHTR1BADRB3HTR1DPDE4DHTR1FHTR1ESLC47A1GHSR
44 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)21 targets overlapping
Amine ligand-binding receptors19 targets overlapping
G alpha (s) signalling events8 targets overlapping
Uncovered Pathway Targets
178 totalADORA2BADORA3ADRB1AGTR1AGTR2APLNRAPPAVPR1AAVPR1BAVPR2+168 more…
Genes present in the top pathway union that Dihydroergotamine does not directly modulate.
Top Stack Candidates
Aripiprazole
score 4,004.037#1 gap-filler · 17 targets covered · evidence score 52.0
ADORA3ADRB1AGTR1AVPR1ACHRM1CHRM2DRD4DRD5HRH1HRH3MLNRTAAR1+5
Astemizole Antihistamine drug now withdrawn from
score 3,898.692#2 gap-filler · 16 targets covered · evidence score 48.7
APLNRAVPR1ACHRM1CHRM2CHRM3DRD4GALR2HRH1HRH4MLNROXTRSSTR5+4
615 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.