BiohacksAI/Mechanism Hypothesis/Dihydrotestosterone

Dihydrotestosterone — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6ARCYP2C9NR1I2ESR1THRBESRRACYP3A4NFE2L2CHAINGLI3PGRRORCNR3C1ABCB1KCNH2RARAESR2CYP19A1ADRB2JUNNR1H4RXRAANDROGENGLUCOCORTICOIDSHBGSERPINA6GPBAR1NLRP3TRHRNR3C2ACTIVATED

33 known targets mapped from PubChem bioassay data

Pathway Context

Nuclear Receptor transcription pathway11 targets overlapping

SUMOylation9 targets overlapping

SUMO E3 ligases SUMOylate target proteins9 targets overlapping

Uncovered Pathway Targets

117 total

ESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1NR1D2NR1H2+107 more…

Genes present in the top pathway union that Dihydrotestosterone does not directly modulate.

Top Stack Candidates

Progesterone

#1 gap-filler · 13 targets covered · evidence score 50.6

score 3,563.845

ESRRGHNF4AHNF4GNR1H2NR2F1NR4A2NR5A1NR5A2RARBRARGRORATP53+1

Luteolin 5,7,3',4'-tetrahydroxy-flavone,

#2 gap-filler · 16 targets covered · evidence score 40.6

score 3,262.846

NR1H2NR1H3PPARGAURKBBLMNFKB2PARP1RELATOP1WRNCBR3CYP1A1+4

626 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.