dofetilide — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C19CYP2D6ARCYP2C9CYTOCHROMECYP3A7NR3C1KCNH2CHRM1DRD3ACHECHRM2MCL1AGTR1SLC18A2VOLTAGE-GATEDKCNH1
17 known targets mapped from PubChem bioassay data
Pathway Context
Biological oxidations4 targets overlapping
Phase I - Functionalization of compounds4 targets overlapping
Cytochrome P450 - arranged by substrate type4 targets overlapping
Uncovered Pathway Targets
195 totalAADACAHCYAHRALDH1A1ALDH2AOC1ARNTCBR3CES1CES2+185 more…
Genes present in the top pathway union that dofetilide does not directly modulate.
Top Stack Candidates
Fluoxetine
score 6,654.376#1 gap-filler · 23 targets covered · evidence score 73.4
CYP3A4ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CCCKBRCHRM3CHRM5CNR1DRD1+11
Astemizole Antihistamine drug now withdrawn from
score 6,241.265#2 gap-filler · 30 targets covered · evidence score 48.7
CYP19A1CYP2J2CYP3A4ADRA1AADRA2AADRA2CADRB2APLNRAVPR1ACHRM3DRD1DRD2+18
856 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.