Doxazosin — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
NR1I2CYTOCHROMETDP1THRBGLI3ABCB1KCNH2CHRM1HOMOADRB2TSHRNTMT1GMNNCHRM4GPR32GPX1MAP4K2GLUTATHIONEABCC4GAASELE
21 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)4 targets overlapping
Amine ligand-binding receptors3 targets overlapping
G alpha (s) signalling events3 targets overlapping
Uncovered Pathway Targets
327 totalADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB3+317 more…
Genes present in the top pathway union that Doxazosin does not directly modulate.
Top Stack Candidates
Fluoxetine
score 7,118.668#1 gap-filler · 26 targets covered · evidence score 73.4
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CCCKBRCHRM3CHRM5CNR1DRD1DRD2+14
Astemizole Antihistamine drug now withdrawn from
score 7,088.034#2 gap-filler · 36 targets covered · evidence score 48.7
ADRA1AADRA2AADRA2CAPLNRAVPR1ACHRM2CHRM3DRD1DRD2DRD3DRD4GALR2+24
1032 more candidates · full stack optimisation locked
Enter your API token to unlock the complete analysis.
BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.