BiohacksAI/Mechanism Hypothesis/Duloxetine Hydrochloride

Duloxetine Hydrochloride — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6CYP1A2CYP3A4KCNH2DRD3ADRA1AHTR2ADRD2DRD1HTR1AADRA2CADRA2BSLC6A3PMP22SLC6A4SLC6A2HTR2CGMNNHRH1HTR6CACNA1CMAP4K2SCN5AKCNQ1GPT2KCNJ2TRPC6SLC18A2MLNRCACNA1DCACNA1FCACNA1SNPBWR1SHMT2KCNE1

36 known targets mapped from PubChem bioassay data

Pathway Context

Class A/1 (Rhodopsin-like receptors)13 targets overlapping

Amine ligand-binding receptors11 targets overlapping

G alpha (q) signalling events6 targets overlapping

Uncovered Pathway Targets

216 total

ADORA2BADORA3ADRA1BADRA1DADRA2AADRB1ADRB2ADRB3AGTR1AGTR2+206 more…

Genes present in the top pathway union that Duloxetine Hydrochloride does not directly modulate.

Top Stack Candidates

Aripiprazole

#1 gap-filler · 22 targets covered · evidence score 52.0

score 4,888.091

ADORA3ADRA1BADRA1DADRA2AADRB1ADRB2ADRB3AGTR1AVPR1ACHRM1CHRM2DRD4+10

Astemizole Antihistamine drug now withdrawn from

#2 gap-filler · 21 targets covered · evidence score 48.7

score 4,785.79

ADRA2AADRB2APLNRAVPR1ACHRM1CHRM2CHRM3DRD4GALR2GHSRHRH2HRH4+9

667 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.