Equilin — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C19ARCYP2C9NR1I2ESR1CYP1A2THRBESRRACYP3A4CHAINGLI3PGRNUCLEARNR3C1ABCB1ESR2SMAD3SMAD2SHBGGFERTAAR1TARDBPHOXA9SMARCA4GNA15AKR1C4RACGAP1P4HB
28 known targets mapped from PubChem bioassay data
Pathway Context
Nuclear Receptor transcription pathway7 targets overlapping
SUMOylation5 targets overlapping
SUMO E3 ligases SUMOylate target proteins5 targets overlapping
Uncovered Pathway Targets
123 totalESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1NR1D2NR1H2+113 more…
Genes present in the top pathway union that Equilin does not directly modulate.
Top Stack Candidates
Bortezomib
score 12,335.364#1 gap-filler · 42 targets covered · evidence score 44.2
PPARDRARAHDAC1HDAC2MITFNFKB2PARP1RELATP53ADRM1HDAC3PSMA1+30
Progesterone
score 4,451.873#2 gap-filler · 17 targets covered · evidence score 50.6
ESRRGHNF4AHNF4GNR1H2NR1H4NR2F1NR3C2NR4A2NR5A1NR5A2RARARARB+5
478 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.