Ergotamine — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYTOCHROMETYROSINE-PROTEINDRD35-HYDROXYTRYPTAMINEADRA1AHTR2ADRD2DRD1HTR1AADRA2AHTR2BADRA2CADRA2BHTR2CPTGS2ALPHA-2AALPHA-2BHTR7HTR6ALPHA-1DALPHA-1AALPHA-2CALPHA-1BHTR1BHTR1DHTR5AHTR1FHTR1EBETA-1BETA-2THROMBOXANE-A
31 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)14 targets overlapping
Amine ligand-binding receptors14 targets overlapping
Serotonin receptors7 targets overlapping
Uncovered Pathway Targets
213 totalADORA2BADORA3ADRA1BADRA1DADRB1ADRB2ADRB3AGTR1AGTR2APLNR+203 more…
Genes present in the top pathway union that Ergotamine does not directly modulate.
Top Stack Candidates
Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on
score 9,745.175#1 gap-filler · 33 targets covered · evidence score 44.3
ADRA1BADRA1DADRB1ADRB2ADRB3DRD4TSHRCREB1GRK2TAS2R1TAS2R10TAS2R13+21
Aripiprazole
score 4,803.59#2 gap-filler · 21 targets covered · evidence score 52.0
ADORA3ADRA1BADRA1DADRB1ADRB2ADRB3AGTR1AVPR1ACHRM1CHRM2DRD4DRD5+9
650 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.