BiohacksAI/Mechanism Hypothesis/Physostigmine

Physostigmine — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6CYP2C9ESR1CYTOCHROMENFE2L2RATTUSTP53EUCHROMATICHTR2APTGS1ACHEMU-TYPEKAPPA-TYPEALDEHYDEGLSADCY9BCHEACETYLCHOLINESTERASECARBOXYLICCHOLINESTERASE

21 known targets mapped from PubChem bioassay data

Pathway Context

Drug ADME4 targets overlapping

Aspirin ADME4 targets overlapping

Neuronal System4 targets overlapping

Uncovered Pathway Targets

218 total

ABCB1ABCC1ABCC2ABCC3ABCC4ABCC5ABCG2ADAADKAKR1C1+208 more…

Genes present in the top pathway union that Physostigmine does not directly modulate.

Top Stack Candidates

Ondansetron

#1 gap-filler · 19 targets covered · evidence score 56.7

score 5,459.176

CHRNA4GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRG2GABRG3+7

Colchicine

#2 gap-filler · 23 targets covered · evidence score 42.1

score 5,307.902

ABCB1SLC22A3GLRA1GLRA2MDM2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBA8+11

832 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.