BiohacksAI/Mechanism Hypothesis/Estrone

Estrone — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

ARCYP2C9NR1I2ESR1ESRRACYP3A7GLI3PGRRORCMUSNUCLEARNR3C1RARA5-HYDROXYTRYPTAMINEESR2CYP19A1IFNGSLC6A3SLC6A4MU-TYPESODIUM-DEPENDENTANDROGENNNMTPNMTGAMTGNMTHNMTCATECHOLSHBGSERPINA6ABCG2ESTROGENTARDBPHSD17B1

34 known targets mapped from PubChem bioassay data

Pathway Context

Nuclear Receptor transcription pathway8 targets overlapping

SUMOylation6 targets overlapping

SUMO E3 ligases SUMOylate target proteins6 targets overlapping

Uncovered Pathway Targets

122 total

ESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1NR1D2NR1H2+112 more…

Genes present in the top pathway union that Estrone does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 41 targets covered · evidence score 44.2

score 12,210.059

PPARDHDAC1HDAC2MITFNFKB2PARP1RELATP53ADRM1HDAC3PSMA1PSMA2+29

Progesterone

#2 gap-filler · 16 targets covered · evidence score 50.6

score 4,308.424

ESRRGHNF4AHNF4GNR1H2NR1H4NR2F1NR3C2NR4A2NR5A1NR5A2RARBRARG+4

437 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.