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BiohacksAI

Evidence-Based Biohacking

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BiohacksAI/Mechanism Hypothesis/Ethidium

Ethidium — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6ARCYP2C9ESR1CYTOCHROMETDP1CYP1A2THRBESRRACYP3A4CYP3A7NFE2L2SYKTYROSINE-PROTEINCHAINGLI3PGRNSD2RORCHISTONE-LYSINENUCLEARTP53RARACHRM1DRD2ESR2CYP19A1AHRPPARGVDRNTMT1ATXN2ACHECFTRNR1H4SMAD3MAPTRXRAIL1BSMAD2POLKMITFCREB1TOP1P1PPARDHTTPPP1R15APOLINR5A1ALOX15PAX8HPGDUSP1GAPDHFEN1POLHNR5A2IP6K1SENP8GRIN1RXFP1GRIN2AGRIN2BPRMT1UHRF1GNAI1RGS12GRIN2CGRIN2DGLP1RMBD2GRIN3AGRIN3BTOP2APSIP1PABPC1TRAABHD4HOXA9TOP1MLLT3CASP6CBFBRUNX1WRNTSTPAFAH1B3SIAEHTRA1PAFAH1B2ACP1PAFAH2TOP2BTERTTDP2TNFERGS100A4

99 known targets mapped from PubChem bioassay data

Pathway Context

SUMOylation16 targets overlapping
SUMO E3 ligases SUMOylate target proteins16 targets overlapping
Nuclear Receptor transcription pathway13 targets overlapping

Uncovered Pathway Targets

149 total
AURKAAURKBBIRC5BLMBRCA1CREBBPCTBP1DNMT1DNMT3BEIF2AK2+139 more…

Genes present in the top pathway union that Ethidium does not directly modulate.

Top Stack Candidates

Quercetin

#1 gap-filler · 19 targets covered · evidence score 43.4

score 4,020.945
AURKBBLMNFKB2NR1I2NR3C1RELAHSP90AA1HSP90AB1HSPB1IGF1RKDM1APIK3R1+7
Progesterone

#2 gap-filler · 13 targets covered · evidence score 50.6

score 3,587.915
NR1H2NR1I2NR3C1NR3C2NR4A2RORAESRRGHNF4AHNF4GNR2F1RARBRARG+1

557 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.