BiohacksAI/Mechanism Hypothesis/Ethylestrenol

Ethylestrenol — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6ARNR1I2ESR1CYTOCHROMETDP1THRBESRRACYP3A4CYP3A7CHAINGLI3PGRNSD2HISTONE-LYSINENUCLEARTP53NR3C1ESR2TSHRNTMT1PMP22NR1H4GMNNSODIUM-DEPENDENTANDROGENKCNMB1KCNMB2MUSCARINICKCNMB4ESTROGENIP6K1LRRC26CIB1ACETYLCHOLINESTERASE

36 known targets mapped from PubChem bioassay data

Pathway Context

Nuclear Receptor transcription pathway8 targets overlapping

SUMOylation7 targets overlapping

SUMO E3 ligases SUMOylate target proteins7 targets overlapping

Uncovered Pathway Targets

120 total

ESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1NR1D2NR1H2+110 more…

Genes present in the top pathway union that Ethylestrenol does not directly modulate.

Top Stack Candidates

Progesterone

#1 gap-filler · 16 targets covered · evidence score 50.6

score 4,118.795

ESRRGHNF4AHNF4GNR1H2NR2F1NR3C2NR4A2NR5A1NR5A2RARARARBRARG+4

Luteolin 5,7,3',4'-tetrahydroxy-flavone,

#2 gap-filler · 18 targets covered · evidence score 40.6

score 3,472.687

NR1H2NR1H3PPARGAURKBBLMNFKB2PARP1RELATOP1WRNCBR3CYP19A1+6

660 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.