BiohacksAI/Mechanism Hypothesis/Ezetimibe

Ezetimibe — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6ARCYP2C9NR1I2CYTOCHROMETHRBESRRACYP3A4CYP3A7SYKTYROSINE-PROTEINPGRNSD2HISTONE-LYSINECHRM1ADRA1AHOMOESR2PPARGPTGS1SMAD3RXRASMAD2ADORA3KCNMB1KCNMB2TBXA2RKCNMB4NPSR1CACNA1HNPC1L1GALNS

33 known targets mapped from PubChem bioassay data

Pathway Context

Nuclear Receptor transcription pathway7 targets overlapping

Biological oxidations6 targets overlapping

Phase I - Functionalization of compounds6 targets overlapping

Uncovered Pathway Targets

226 total

ESR1ESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1NR1D2+216 more…

Genes present in the top pathway union that Ezetimibe does not directly modulate.

Top Stack Candidates

Astemizole Antihistamine drug now withdrawn from

#1 gap-filler · 33 targets covered · evidence score 48.7

score 6,753.911

ESR1PPARDRARACYP19A1CYP2J2ADRA2AADRA2CADRB2APLNRAVPR1ACHRM2CHRM3+21

Fluoxetine

#2 gap-filler · 23 targets covered · evidence score 73.4

score 6,637.404

ESR1RARAADRA1BADRA1DADRA2AADRA2BADRA2CCCKBRCHRM3CHRM5CNR1DRD1+11

906 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.