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BiohacksAI

Evidence-Based Biohacking

Patent Pending
BiohacksAI/Mechanism Hypothesis/Fluoxetine

Fluoxetine — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6ARESR1THRBCYP3A4CYP3A7SYKGLI3NSD2KCNH2RARAADRA1AHTR2ADRD2ESR2DRD1HTR1AADRA2AHTR2BADRA2CJUNADRA2BATXN2SLC6A3ACHESLC6A4SLC6A2SMAD3HTR2CSTK33HRH1SMAD2CHRM5ADRA1BADRA1DCHRM3HRH2HTR6HTR1BHTR1DGPR32CACNA1CSIGMAR1HTR1FHRH3NPR2CNR1SLC18A2MC3RTOR1AEDNRACCKBRKCNJ6SLC29A4KCNC1

56 known targets mapped from PubChem bioassay data

Pathway Context

Class A/1 (Rhodopsin-like receptors)22 targets overlapping
Amine ligand-binding receptors18 targets overlapping
G alpha (q) signalling events11 targets overlapping

Uncovered Pathway Targets

177 total
ADORA2BADORA3ADRB1ADRB2ADRB3AGTR1AGTR2APLNRAPPAVPR1A+167 more…

Genes present in the top pathway union that Fluoxetine does not directly modulate.

Top Stack Candidates

Astemizole Antihistamine drug now withdrawn from

#1 gap-filler · 18 targets covered · evidence score 48.7

score 4,219.321
ADRB2APLNRAVPR1ACHRM1CHRM2DRD3DRD4GALR2GHSRHRH4HTR7MLNR+6
Aripiprazole

#2 gap-filler · 18 targets covered · evidence score 52.0

score 4,078.754
ADORA3ADRB1ADRB2ADRB3AGTR1AVPR1ACHRM1CHRM2DRD3DRD4DRD5HTR7+6

655 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.