BiohacksAI/Mechanism Hypothesis/Flutamide

Flutamide — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6ARCYP2C9NR1I2ESR1CYTOCHROMETDP1CYP1A2THRBESRRACYP3A4CYP3A7NFE2L2SYKTYROSINE-PROTEINGLI3PGRRATTUSRORCNUCLEARABCB1KCNH2RARAEUCHROMATICCHRM15-HYDROXYTRYPTAMINEADRA1AHOMOHTR2ADRD2ESR2CYP19A1SMAD3RXRASMAD2ANDROGENTBXA2RKCNMA1INSAADACCES2

42 known targets mapped from PubChem bioassay data

Pathway Context

Biological oxidations10 targets overlapping

Phase I - Functionalization of compounds10 targets overlapping

Cytochrome P450 - arranged by substrate type8 targets overlapping

Uncovered Pathway Targets

110 total

AHCYAHRALDH1A1ALDH2AOC1ARNTCBR3CES1CYP11B1CYP11B2+100 more…

Genes present in the top pathway union that Flutamide does not directly modulate.

Top Stack Candidates

Progesterone

#1 gap-filler · 17 targets covered · evidence score 50.6

score 4,641.631

NR1H4ESRRGHNF4AHNF4GNR1H2NR2F1NR3C1NR3C2NR4A2NR5A1NR5A2RARB+5

Gemfibrozil

#2 gap-filler · 13 targets covered · evidence score 51.5

score 3,510.202

AHRCYP2C8NR1H2NR2F1NR5A1NR5A2PPARARARBRARGRORAABCC2SLCO1B1+1

539 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.