Fulvestrant — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C19ARCYP2C9NR1I2ESR1THRBESRRACYP3A4NFE2L2GLI3PGRRORCMUSNR3C1ESR2CYP19A1IFNGNR1H4ESTROGENSIRT5PROTEINEPHX2DHCR24GPER1
24 known targets mapped from PubChem bioassay data
Pathway Context
Nuclear Receptor transcription pathway8 targets overlapping
SUMOylation6 targets overlapping
SUMO E3 ligases SUMOylate target proteins6 targets overlapping
Uncovered Pathway Targets
121 totalESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1NR1D2NR1H2+111 more…
Genes present in the top pathway union that Fulvestrant does not directly modulate.
Top Stack Candidates
Progesterone
score 4,251.831#1 gap-filler · 17 targets covered · evidence score 50.6
ESRRGHNF4AHNF4GNR1H2NR2F1NR3C2NR4A2NR5A1NR5A2RARARARBRARG+5
Gemfibrozil
score 3,267.311#2 gap-filler · 13 targets covered · evidence score 51.5
NR1H2NR2F1NR5A1NR5A2PPARARARARARBRARGRORARXRAAHRCYP1A2+1
729 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.