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BiohacksAI

Evidence-Based Biohacking

Patent Pending
BiohacksAI/Mechanism Hypothesis/Genistein

Genistein — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19ARCYP2C9NR1I2ESR1CYP1A2THRBESRRACYP3A4NFE2L2GLI3PGRTP53NR3C1RARAHTR2AESR2AHRPPARGATAD5PMP22CFTRNR1H4RXRAIFNB1CREB1YAP1HDAC9PPARDHLA-BHDAC6MAOAHPGDSLCO1B1NR0B1THPOSNCAABCG2ABL1MAOBSLCO1B3SMN2TTRSLCO2B1CLK1ADORA1TOP2APSMB5XDHDPP4RAB9APIM2NPC1FYNSMARCA4PRKNSMARCA2TRPC5SLC2A1HSD17B1ESRRGSULT1A1AOX1GBA1GEMMGAMESRRBITPKCMAP2K4

69 known targets mapped from PubChem bioassay data

Pathway Context

Nuclear Receptor transcription pathway15 targets overlapping
SUMOylation11 targets overlapping
SUMO E3 ligases SUMOylate target proteins11 targets overlapping

Uncovered Pathway Targets

109 total
HNF4AHNF4GNCOR1NCOR2NR1D1NR1D2NR1H2NR1H3NR1I3NR2C1+99 more…

Genes present in the top pathway union that Genistein does not directly modulate.

Top Stack Candidates

Progesterone

#1 gap-filler · 12 targets covered · evidence score 50.6

score 3,353.135
HNF4AHNF4GNR1H2NR2F1NR3C2NR4A2NR5A1NR5A2RARBRARGRORACYP2D6
Luteolin 5,7,3',4'-tetrahydroxy-flavone,

#2 gap-filler · 14 targets covered · evidence score 40.6

score 2,988.714
NR1H2NR1H3AURKBBLMNFKB2PARP1RELATOP1WRNCBR3CYP19A1CYP1A1+2

614 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.