Heme — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
NR1D1NR1D2
2 known targets mapped from PubChem bioassay data
Pathway Context
Nuclear Receptor transcription pathway2 targets overlapping
Uncovered Pathway Targets
40 totalARESR1ESR2ESRRAESRRBESRRGHNF4AHNF4GNCOR1NCOR2+30 more…
Genes present in the top pathway union that Heme does not directly modulate.
Top Stack Candidates
Progesterone
score 4,939.76#1 gap-filler · 22 targets covered · evidence score 50.6
ARESR1ESR2ESRRAESRRGHNF4AHNF4GNR1H2NR1H4NR1I2NR2F1NR3C1+10
Aldosterone
score 2,875.637#2 gap-filler · 13 targets covered · evidence score 44.6
ARESRRGHNF4GNR2C1NR3C1NR3C2NR4A2NR5A1NR5A2PGRPPARARORB+1
592 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.