BiohacksAI/Mechanism Hypothesis/Idazoxan

Idazoxan — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2D6ARNR1I2TDP1THRBESRRANFE2L2GLI3PGRRATTUSNSD2RORCHISTONE-LYSINENUCLEARTP53RARAADRA1AESR2CYP19A1ADRA2AVDRTSHRADRA2CADRA2BATXN2ATAD5NR1H4SMAD3GMNNSMAD2ADRA1BADRA1DPPARDHSPB1HTTMAOAMTORTXNRD1IP6K1MAOBNISCH

41 known targets mapped from PubChem bioassay data

Pathway Context

Nuclear Receptor transcription pathway9 targets overlapping

Class A/1 (Rhodopsin-like receptors)7 targets overlapping

SUMOylation7 targets overlapping

Uncovered Pathway Targets

208 total

ESR1ESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1NR1D2+198 more…

Genes present in the top pathway union that Idazoxan does not directly modulate.

Top Stack Candidates

Astemizole Antihistamine drug now withdrawn from

#1 gap-filler · 31 targets covered · evidence score 48.7

score 6,353.473

ESR1PPARGADRB2APLNRAVPR1ACHRM1CHRM2CHRM3DRD1DRD2DRD3DRD4+19

Aripiprazole

#2 gap-filler · 28 targets covered · evidence score 52.0

score 5,761.813

ESR1ADORA3ADRB1ADRB2ADRB3AGTR1AVPR1ACHRM1CHRM2DRD1DRD2DRD3+16

850 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.