BiohacksAI/Mechanism Hypothesis/Imatinib Mesylate

Imatinib Mesylate — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

ARNR1I2TDP1THRBESRRACYP3A7TYROSINE-PROTEINGLI3PGRNSD2HISTONE-LYSINENUCLEARHOMOHTR2AESR2AHRTSHRNR1H4IDH1CREB1MAP4K2ABL1KCNMA1RAD52BACE1KITCYP2C8BCRPLATELET-DERIVED

29 known targets mapped from PubChem bioassay data

Pathway Context

Nuclear Receptor transcription pathway6 targets overlapping

SUMOylation5 targets overlapping

SUMO E3 ligases SUMOylate target proteins5 targets overlapping

Uncovered Pathway Targets

123 total

ESR1ESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1NR1D2+113 more…

Genes present in the top pathway union that Imatinib Mesylate does not directly modulate.

Top Stack Candidates

Progesterone

#1 gap-filler · 21 targets covered · evidence score 50.6

score 4,703.121

ESR1ESRRGHNF4AHNF4GNR1H2NR2F1NR3C1NR3C2NR4A2NR5A1NR5A2RARA+9

Luteolin 5,7,3',4'-tetrahydroxy-flavone,

#2 gap-filler · 20 targets covered · evidence score 40.6

score 3,645.549

NR1H2NR1H3PPARGAURKBBLMNFKB2PARP1RELATOP1WRNCBR3CYP19A1+8

814 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.