Itraconazole — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
ARCYP2C9NR1I2ESR1CYTOCHROMETHRBESRRACYP3A4CYP3A7NFE2L2SYKTYROSINE-PROTEINGLI3NSD2RORCHISTONE-LYSINEESR2NR1H4
18 known targets mapped from PubChem bioassay data
Pathway Context
Nuclear Receptor transcription pathway6 targets overlapping
Biological oxidations4 targets overlapping
Phase I - Functionalization of compounds4 targets overlapping
Uncovered Pathway Targets
124 totalESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1NR1D2NR1H2+114 more…
Genes present in the top pathway union that Itraconazole does not directly modulate.
Top Stack Candidates
Progesterone
score 4,613.984#1 gap-filler · 20 targets covered · evidence score 50.6
ESRRGHNF4AHNF4GNR1H2NR2F1NR3C1NR3C2NR4A2NR5A1NR5A2PGRRARA+8
Quercetin
score 3,672.266#2 gap-filler · 21 targets covered · evidence score 43.4
NR3C1PGRPPARGRXRAAHRCYP19A1CYP1A1CYP1A2CYP1B1CYP2C19CYP2C8HSP90AB1+9
781 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.