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BiohacksAI

Evidence-Based Biohacking

Patent Pending
BiohacksAI/Mechanism Hypothesis/Leflunomide

Leflunomide — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6CYP2C9NR1I2ESR1CYTOCHROMETDP1CYP1A2THRBESRRACYP3A4NFE2L2GLI3PGRRATTUSNSD2MUSHISTONE-LYSINENUCLEARRARA5-HYDROXYTRYPTAMINEHOMODRD2DRD1AHRATAD5SLC6A3SLC6A2SODIUM-DEPENDENTIFNB1CASP3HDAC9HSPB1HLA-BHTTNR0B1SENP8SMN2RAB9ASENP6SENP7MMP14HLAARYLDHODH

45 known targets mapped from PubChem bioassay data

Pathway Context

Biological oxidations6 targets overlapping
Phase I - Functionalization of compounds6 targets overlapping
Cytochrome P450 - arranged by substrate type6 targets overlapping

Uncovered Pathway Targets

85 total
AADACAHCYALDH1A1ALDH2AOC1ARNTCBR3CES1CES2CYP11B1+75 more…

Genes present in the top pathway union that Leflunomide does not directly modulate.

Top Stack Candidates

Progesterone

#1 gap-filler · 17 targets covered · evidence score 50.6

score 4,330.588
NR1H4RXRAARESR2ESRRGHNF4AHNF4GNR1H2NR2F1NR3C1NR3C2NR4A2+5
Aldosterone

#2 gap-filler · 13 targets covered · evidence score 44.6

score 3,078.504
RXRAARESRRGHNF4GNR1D1NR2C1NR3C1NR3C2NR4A2NR5A1NR5A2PPARA+1

581 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.