BiohacksAI/Mechanism Hypothesis/Lisuride

Lisuride — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYTOCHROMEABCB1DRD35-HYDROXYTRYPTAMINEADRA1AHTR2ADRD2DRD1HTR1AADRA2AADRB2HTR2BADRA2CADRA2BHTR2CALPHA-2AADRB1ADRA1BALPHA-2BHRH2HTR7HTR6ALPHA-1DALPHA-1AALPHA-2CDRD4ALPHA-1BHTR1BHTR1DHTR5AHISTAMINEHTR1EDRD5BETA-1BETA-2CPT2

36 known targets mapped from PubChem bioassay data

Pathway Context

Class A/1 (Rhodopsin-like receptors)20 targets overlapping

Amine ligand-binding receptors20 targets overlapping

G alpha (s) signalling events7 targets overlapping

Uncovered Pathway Targets

158 total

ADORA2BADORA3ADRA1DADRB3AGTR1AGTR2APLNRAPPAVPR1AAVPR1B+148 more…

Genes present in the top pathway union that Lisuride does not directly modulate.

Top Stack Candidates

Astemizole Antihistamine drug now withdrawn from

#1 gap-filler · 16 targets covered · evidence score 48.7

score 3,831.629

APLNRAVPR1ACHRM1CHRM2CHRM3GALR2GHSRHRH1HRH4MLNROXTRSSTR5+4

Fluoxetine

#2 gap-filler · 10 targets covered · evidence score 73.4

score 3,526.377

ADRA1DCCKBRCHRM3CHRM5CNR1EDNRAHRH1HRH3MC3RGPR32

590 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.