BiohacksAI/Mechanism Hypothesis/Lithocholic Acid

Lithocholic Acid — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2D6NR1I2THRBESRRANFE2L2TYROSINE-PROTEINPGRNR3C1ABCB1RARAHTR2AESR2VDRJUNNR1H4CASP3HSPB1CASP7GNRHRGPBAR1SNCAMAPK1NLRP3KAT2ASENP8TRHRPTPN1PLK1HSPD1HSPE1CTDSP1G-PROTEINPTPN2

33 known targets mapped from PubChem bioassay data

Pathway Context

Nuclear Receptor transcription pathway8 targets overlapping

SUMOylation6 targets overlapping

SUMO E3 ligases SUMOylate target proteins6 targets overlapping

Uncovered Pathway Targets

120 total

ARESR1ESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1+110 more…

Genes present in the top pathway union that Lithocholic Acid does not directly modulate.

Top Stack Candidates

Progesterone

#1 gap-filler · 16 targets covered · evidence score 50.6

score 4,108.133

ARESR1ESRRGHNF4AHNF4GNR1H2NR2F1NR3C2NR4A2NR5A1NR5A2RARB+4

Quercetin

#2 gap-filler · 19 targets covered · evidence score 43.4

score 3,835.857

ARESR1PPARGRXRAAURKBBLMNFKB2RELATOP1TOP2ATP53CREB1+7

619 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.