lonidamine — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2D6CYP2C9NR1I2ESR1THRBESRRANFE2L2NR3C1EUCHROMATICPPARGGPR32THYROIDPROTEINCRBNHK2
15 known targets mapped from PubChem bioassay data
Pathway Context
Nuclear Receptor transcription pathway5 targets overlapping
SUMOylation4 targets overlapping
SUMO E3 ligases SUMOylate target proteins4 targets overlapping
Uncovered Pathway Targets
126 totalARESR2ESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1+116 more…
Genes present in the top pathway union that lonidamine does not directly modulate.
Top Stack Candidates
Bortezomib
score 12,670.358#1 gap-filler · 45 targets covered · evidence score 44.2
ARESR2PGRPPARDRARAHDAC1HDAC2MITFNFKB2PARP1RELATP53+33
Progesterone
score 4,960.475#2 gap-filler · 21 targets covered · evidence score 50.6
ARESR2ESRRGHNF4AHNF4GNR1H2NR1H4NR2F1NR3C2NR4A2NR5A1NR5A2+9
613 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.