Loratadine — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C19CYP2D6ARCYP2C9NR1I2ESR1CYTOCHROMETDP1THRBESRRACYP3A7NFE2L2SYKTYROSINE-PROTEINGLI3PGRRORCNUCLEARTP53ABCB1KCNH2RARACHRM1DRD35-HYDROXYTRYPTAMINEHOMOHTR2AESR2PPARGADRB2HTR2BATXN2SLC6A3NR1H4MU-TYPESMAD3KAPPA-TYPEGMNNCHRM2HRH1SMAD2HIF1AADORA3HRH2PPARDADRB3RAPGEF4HISTAMINEMAPK1NPSR1ANO1THYROIDCACNA1HKCNQ2CYP2C8PHOSPHO1SLC6A15
57 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)11 targets overlapping
Nuclear Receptor transcription pathway10 targets overlapping
Amine ligand-binding receptors9 targets overlapping
Uncovered Pathway Targets
203 totalADORA2BADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1AGTR1AGTR2+193 more…
Genes present in the top pathway union that Loratadine does not directly modulate.
Top Stack Candidates
Fluoxetine
score 5,441.39#1 gap-filler · 18 targets covered · evidence score 73.4
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CCCKBRCHRM3CHRM5CNR1DRD1DRD2+6
Astemizole Antihistamine drug now withdrawn from
score 5,405.142#2 gap-filler · 25 targets covered · evidence score 48.7
ADRA1AADRA2AADRA2CAPLNRAVPR1ACHRM3DRD1DRD2DRD4GALR2GHSRHRH4+13
781 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.