BiohacksAI/Mechanism Hypothesis/Losartan

Losartan — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C9CYTOCHROMECYP3A4CYP3A7GLI3RATTUSMUSADRA1AHOMOPPARGHTR2CABCB11ADRA1BADRA1DTBXA2RSLCO1B1CGMP-INHIBITEDSLCO1B3AGTR1CNR1ACEAGTR1AAGTR1BAGTR2GP6TYPE-2TYPE-1

27 known targets mapped from PubChem bioassay data

Pathway Context

Class A/1 (Rhodopsin-like receptors)8 targets overlapping

G alpha (q) signalling events6 targets overlapping

Drug ADME4 targets overlapping

Uncovered Pathway Targets

206 total

ADORA2BADORA3ADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APLNRAPP+196 more…

Genes present in the top pathway union that Losartan does not directly modulate.

Top Stack Candidates

Astemizole Antihistamine drug now withdrawn from

#1 gap-filler · 32 targets covered · evidence score 48.7

score 6,418.448

ADRA2AADRA2CADRB2APLNRAVPR1ACHRM1CHRM2CHRM3DRD1DRD2DRD3DRD4+20

Aripiprazole

#2 gap-filler · 30 targets covered · evidence score 52.0

score 6,050.728

ADORA3ADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AVPR1ACHRM1CHRM2DRD1DRD2+18

922 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.