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Evidence-Based Biohacking

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BiohacksAI/Mechanism Hypothesis/Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is

Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6NR1I2ESR1TDP1THRBCYP3A4CYP3A7SYKTYROSINE-PROTEINCHAINDRD35-HYDROXYTRYPTAMINEADRA1AHTR2ADRD2DRD1AHRHTR1AADRA2AADRB2HTR2BNTMT1ACHEHTR2CHRH1ADRB1ADRA1BHTR7HTR6DRD4HTR1BHTR1DHTR5AIP6K1HTR1EDRD5CIB1CPT2

39 known targets mapped from PubChem bioassay data

Pathway Context

Amine ligand-binding receptors18 targets overlapping
Serotonin receptors7 targets overlapping

Uncovered Pathway Targets

182 total
ADORA2BADORA3ADRA1DADRA2BADRA2CADRB3AGTR1AGTR2APLNRAPP+172 more…

Genes present in the top pathway union that Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is does not directly modulate.

Top Stack Candidates

Astemizole Antihistamine drug now withdrawn from

#1 gap-filler · 18 targets covered · evidence score 48.7

score 4,291.359
ADRA2CAPLNRAVPR1ACHRM1CHRM2CHRM3GALR2GHSRHRH2HRH4MLNROXTR+6
Aripiprazole

#2 gap-filler · 18 targets covered · evidence score 52.0

score 4,139.617
ADORA3ADRA1DADRA2BADRA2CADRB3AGTR1AVPR1ACHRM1CHRM2HRH2HRH3MLNR+6

643 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.