Medroxyprogesterone — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C19CYP2D6ARCYTOCHROMETDP1THRBESRRACYP3A7GLI3PGRNSD2HISTONE-LYSINENUCLEARNR3C1CFTRANDROGENCHRM4GLUCOCORTICOID
18 known targets mapped from PubChem bioassay data
Pathway Context
Nuclear Receptor transcription pathway4 targets overlapping
Transcriptional regulation by RUNX24 targets overlapping
Biological oxidations3 targets overlapping
Uncovered Pathway Targets
142 totalESR1ESR2ESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1+132 more…
Genes present in the top pathway union that Medroxyprogesterone does not directly modulate.
Top Stack Candidates
Bortezomib
score 11,576.011#1 gap-filler · 41 targets covered · evidence score 44.2
ESR1ESR2NR1I2PPARDRARAADRM1HDAC3PSMA1PSMA2PSMA3PSMA4PSMA5+29
Progesterone
score 4,909.975#2 gap-filler · 21 targets covered · evidence score 50.6
ESR1ESR2ESRRGHNF4AHNF4GNR1H2NR1H4NR1I2NR2F1NR3C2NR4A2NR5A1+9
762 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.