BiohacksAI/Mechanism Hypothesis/Medroxyprogesterone Acetate

Medroxyprogesterone Acetate — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19ARCYP2C9NR1I2TDP1THRBESRRACYP3A4CYP3A7NFE2L2SYKTYROSINE-PROTEINGLI3PGRRATTUSNSD2RORCHISTONE-LYSINENUCLEARNR3C1RARAHOMOESR2JUNCFTRALDEHYDEANDROGENGLUCOCORTICOIDSHBGESTROGENNPSR1NR3C2PRKNAKR1C3PINK1AKR1C2ERGAKR1C1

38 known targets mapped from PubChem bioassay data

Pathway Context

Nuclear Receptor transcription pathway8 targets overlapping

SUMOylation6 targets overlapping

SUMO E3 ligases SUMOylate target proteins6 targets overlapping

Uncovered Pathway Targets

121 total

ESR1ESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1NR1D2+111 more…

Genes present in the top pathway union that Medroxyprogesterone Acetate does not directly modulate.

Top Stack Candidates

Progesterone

#1 gap-filler · 16 targets covered · evidence score 50.6

score 4,165.462

ESR1ESRRGHNF4AHNF4GNR1H2NR1H4NR2F1NR4A2NR5A1NR5A2RARBRARG+4

Quercetin

#2 gap-filler · 19 targets covered · evidence score 43.4

score 3,927.293

ESR1PPARGRXRAAURKBBLMNFKB2RELATOP1TOP2ATP53CREB1HSP90AA1+7

569 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.