BiohacksAI/Mechanism Hypothesis/Megestrol Acetate Megestrol acetate is

Megestrol Acetate Megestrol acetate is — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19ARCYP2C9NR1I2CYTOCHROMETDP1THRBESRRACYP3A7NFE2L2SYKTYROSINE-PROTEINPGRRORCNUCLEARNR3C1RARAHOMOESR2ANDROGENABCB11GLUCOCORTICOIDNPSR1GAMMA-AMINOBUTYRIC

24 known targets mapped from PubChem bioassay data

Pathway Context

Nuclear Receptor transcription pathway7 targets overlapping

SUMOylation5 targets overlapping

SUMO E3 ligases SUMOylate target proteins5 targets overlapping

Uncovered Pathway Targets

123 total

ESR1ESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1NR1D2+113 more…

Genes present in the top pathway union that Megestrol Acetate Megestrol acetate is does not directly modulate.

Top Stack Candidates

Progesterone

#1 gap-filler · 18 targets covered · evidence score 50.6

score 4,400.48

ESR1ESRRGHNF4AHNF4GNR1H2NR1H4NR2F1NR3C2NR4A2NR5A1NR5A2RARB+6

Quercetin

#2 gap-filler · 20 targets covered · evidence score 43.4

score 3,558.482

ESR1PPARGRXRAAURKBBLMNFKB2RELATOP1TOP2ATP53AHRCYP19A1+8

780 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.