BiohacksAI/Mechanism Hypothesis/Mestranol

Mestranol — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6ARCYP2C9NR1I2ESR1CYTOCHROMETDP1CYP1A2CYP3A4CYP3A7NFE2L2SYKTYROSINE-PROTEINPGRNUCLEARNR3C1DRD3HTR2AESR2TSHRJUNSLC6A4CFTRSODIUM-DEPENDENTANDROGENGPR32ESTROGENIP6K1DDIT3MAP1LC3A

31 known targets mapped from PubChem bioassay data

Pathway Context

Biological oxidations6 targets overlapping

Phase I - Functionalization of compounds6 targets overlapping

Cytochrome P450 - arranged by substrate type6 targets overlapping

Uncovered Pathway Targets

85 total

AADACAHCYAHRALDH1A1ALDH2AOC1ARNTCBR3CES1CES2+75 more…

Genes present in the top pathway union that Mestranol does not directly modulate.

Top Stack Candidates

Progesterone

#1 gap-filler · 16 targets covered · evidence score 50.6

score 4,195.996

NR1H4RXRAESRRAESRRGHNF4AHNF4GNR1H2NR2F1NR3C2NR4A2NR5A1NR5A2+4

Gemfibrozil

#2 gap-filler · 13 targets covered · evidence score 51.5

score 3,267.987

AHRCYP2C8RXRAESRRANR1H2NR2F1NR5A1NR5A2PPARARARARARBRARG+1

504 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.