Methysergide — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2D6CYTOCHROMECYP3A7SYKTYROSINE-PROTEINCHAINEUCHROMATICDRD35-HYDROXYTRYPTAMINEADRA1AHTR2ADRD2DRD1AHRHTR1AADRA2AVDRHTR2BADRA2CADRA2BACHEHTR2CALDEHYDEHRH1ALPHA-2ANNMTPNMTALPHA-2BHRH2HTR7GAMTGNMTHNMTHTR6CATECHOLHTR1BRGS4HTR1DHTR5ATXNRD1HTR1FHTR1ECIB1MYC
44 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)16 targets overlapping
Amine ligand-binding receptors16 targets overlapping
Serotonin receptors7 targets overlapping
Uncovered Pathway Targets
210 totalADORA2BADORA3ADRA1BADRA1DADRB1ADRB2ADRB3AGTR1AGTR2APLNR+200 more…
Genes present in the top pathway union that Methysergide does not directly modulate.
Top Stack Candidates
Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on
score 9,745.175#1 gap-filler · 33 targets covered · evidence score 44.3
ADRA1BADRA1DADRB1ADRB2ADRB3DRD4TSHRCREB1GRK2TAS2R1TAS2R10TAS2R13+21
Aripiprazole
score 4,170.512#2 gap-filler · 18 targets covered · evidence score 52.0
ADORA3ADRA1BADRA1DADRB1ADRB2ADRB3AGTR1AVPR1ACHRM1CHRM2DRD4DRD5+6
630 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.